Key result
Systolic cardiac T2 mapping demonstrated significantly higher precision compared to diastolic T2 mapping (segmental standard deviation 4.5 ms vs 5.1 ms, P=0.002) in healthy volunteers.
Observational (n=11)
No
Systolic radial T2 mapping at 3T provides higher precision than diastolic mapping, though the technique is vulnerable to off-resonance frequencies beyond ±100 Hz.
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Requires prospective validation in patients before clinical use; extends technical optimization of cardiac T2 mapping at 3T.
Purpose The goal of this study was to characterize the accuracy and precision of cardiac T 2 mapping as a function of different factors including low signal‐to‐noise ratio (SNR), imaging in systole, and off‐resonance frequencies. Methods Bloch equation and Monte Carlo simulations were used to determine the influence of SNR and the choice of T 2 preparation echo time (TE T2prep ) increments on the accuracy and precision of high‐resolution radial cardiac T 2 mapping at 3.0 T. Healthy volunteers were scanned to establish the difference in precision and inter‐ and intraobserver variability between T 2 mapping in diastole and systole, as well as the effect of SNR and off‐resonance frequencies on the accuracy of T 2 maps. Results The simulations demonstrated that a TE T2prep increment of ∼0.75 times the T 2 value of interest optimally increases the precision of the T 2 fit. Systolic T 2 maps were found to have a higher precision ( P = 0.002), but similar inter‐ and intraobserver variability compared with diastolic T 2 maps, whereas off‐resonance frequencies beyond ± 100 Hz cause a significant decrease in both accuracy and precision ( P < 0.05). Conclusion This evaluation of the accuracy and precision of cardiac T 2 mapping characterizes the major vulnerabilities of the technique and will help guide protocol definition of studies that include T 2 mapping. Magn Reson Med 77:159–169, 2017.
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Bano et al. (2016) conducted an observational in Healthy volunteers (n=11). Cardiac T2 mapping in systole vs. Cardiac T2 mapping in diastole was evaluated on Precision of T2 maps (segmental standard deviation in ms) (p=0.002). Systolic cardiac T2 mapping demonstrated significantly higher precision compared to diastolic T2 mapping (segmental standard deviation 4.5 ms vs 5.1 ms, P=0.002) in healthy volunteers.
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