What does this research mean for the field?

Potassium supplementation significantly lowers office, home, and 24-hour blood pressure in patients with essential hypertension, particularly in those with higher baseline blood pressure and lower baseline potassium intake. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

To assess the effects of oral potassium supplementation on office, home, and 24-hour ambulatory blood pressure in patients with essential hypertension.

October 1, 1998American Journal of HypertensionOpen Access

Effects of potassium supplementation on office, home, and 24-h blood pressure in patients with essential hypertension☆

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Why the study?

Does potassium supplementation reduce office, home, and 24-h blood pressure in patients with essential hypertension?

Population

55 patients with essential hypertension (26 men, 29 women, 36-77 years old)

Comparison

Potassium supplementation for 4 weeks vs 4-week control period

Design

RCT, randomized crossover manner

Follow-up

4 weeks per period

Authors

YKYuhei KawanoPreventive Cardiology JMJ. MinamiThrombosis Research Institute STShuichi TakishitaKagoshima University

Discussion

Member takes

Implication

Supports potassium supplementation in essential hypertension; confirms BP-lowering effect in RCT despite prior inconsistent trials.

Key Points

To assess the effects of oral potassium supplementation on office, home, and 24-hour ambulatory blood pressure in patients with essential hypertension.
Randomized crossover trial of 55 patients with essential hypertension (26 men, 29 women; aged 36–77 years).
Compared 4 weeks of potassium supplementation (64 mmol/day slow-release KCl tablets) with a 4-week control period.
Assessed office, home, and 24-hour ambulatory blood pressure, along with serum and urinary electrolytes, at the end of each period.
Potassium supplementation significantly reduced office BP by 2.7 ± 1.1 / 1.4 ± 0.6 mm Hg (P < .05 for SBP), home BP by 3.6 ± 0.9 / 1.7 ± 0.5 mm Hg (P < .001 for SBP), and 24-hour BP by 3.4 ± 1.0 / 1.2 ± 0.5 mm Hg (P < .001 for SBP).
Serum potassium rose from 4.15 ± 0.04 to 4.42 ± 0.05 mmol/L and urinary potassium excretion increased from 54 ± 2 to 96 ± 3 mmol/day.
The magnitude of 24-hour systolic BP reduction correlated negatively with baseline BP and urinary sodium-to-potassium ratio, and daytime and nighttime reductions were comparable.

Structured PICO

Does potassium supplementation reduce office, home, and 24-h blood pressure in patients with essential hypertension?

Population

55 patients with essential hypertension (26 men, 29 women, 36-77 years old)

Intervention

Potassium supplementation (64 mmol/day of K as slow-release KCl tablets) for 4 weeks

Comparator

4-week control period (randomized crossover design)

Outcome

Office, home, and 24-h blood pressuresurrogate

Potassium supplementation (64 mmol/day) modestly but significantly lowers office, home, and 24-h blood pressure in patients with essential hypertension.

Cite This Study

Kawano et al. (1998) studied this question.

synapsesocial.com/papers/6a19505eff42a97fac5809fd https://doi.org/10.1016/s0895-7061(98)00037-5

Topics

Hypertension management

View Full Paper

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October 1, 1998American Journal of HypertensionOpen Access

Effects of potassium supplementation on office, home, and 24-h blood pressure in patients with essential hypertension☆

View Full Paper

Ask AI

Bookmark

Why the study?

Does potassium supplementation reduce office, home, and 24-h blood pressure in patients with essential hypertension?

Population

55 patients with essential hypertension (26 men, 29 women, 36-77 years old)

Comparison

Potassium supplementation for 4 weeks vs 4-week control period

Design

RCT, randomized crossover manner

Follow-up

4 weeks per period

Authors

YKYuhei KawanoPreventive Cardiology JMJ. MinamiThrombosis Research Institute STShuichi TakishitaKagoshima University

Discussion

Member takes

Implication

Supports potassium supplementation in essential hypertension; confirms BP-lowering effect in RCT despite prior inconsistent trials.

Key Points

To assess the effects of oral potassium supplementation on office, home, and 24-hour ambulatory blood pressure in patients with essential hypertension.
Randomized crossover trial of 55 patients with essential hypertension (26 men, 29 women; aged 36–77 years).
Compared 4 weeks of potassium supplementation (64 mmol/day slow-release KCl tablets) with a 4-week control period.
Assessed office, home, and 24-hour ambulatory blood pressure, along with serum and urinary electrolytes, at the end of each period.
Potassium supplementation significantly reduced office BP by 2.7 ± 1.1 / 1.4 ± 0.6 mm Hg (P < .05 for SBP), home BP by 3.6 ± 0.9 / 1.7 ± 0.5 mm Hg (P < .001 for SBP), and 24-hour BP by 3.4 ± 1.0 / 1.2 ± 0.5 mm Hg (P < .001 for SBP).
Serum potassium rose from 4.15 ± 0.04 to 4.42 ± 0.05 mmol/L and urinary potassium excretion increased from 54 ± 2 to 96 ± 3 mmol/day.
The magnitude of 24-hour systolic BP reduction correlated negatively with baseline BP and urinary sodium-to-potassium ratio, and daytime and nighttime reductions were comparable.

Structured PICO

Does potassium supplementation reduce office, home, and 24-h blood pressure in patients with essential hypertension?

Population

55 patients with essential hypertension (26 men, 29 women, 36-77 years old)

Intervention

Potassium supplementation (64 mmol/day of K as slow-release KCl tablets) for 4 weeks

Comparator

4-week control period (randomized crossover design)

Outcome

Office, home, and 24-h blood pressuresurrogate

Potassium supplementation (64 mmol/day) modestly but significantly lowers office, home, and 24-h blood pressure in patients with essential hypertension.

Cite This Study

Kawano et al. (1998) studied this question.

synapsesocial.com/papers/6a19505eff42a97fac5809fd https://doi.org/10.1016/s0895-7061(98)00037-5

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Topics

Hypertension management

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