What does this research mean for the field?

An E box binding basic helix-loop-helix protein regulates the cardiac muscle-specific expression of the cytochrome oxidase subunit VIII (COX VIII(H)) promoter. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 1, 1996Journal of Biological ChemistryOpen Access

The Role of an E Box Binding Basic Helix Loop Helix Protein in the Cardiac Muscle-specific Expression of the Rat Cytochrome Oxidase Subunit VIII Gene

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Population

C2C12 skeletal myocytes and H9C2 cardiomyocytes

Design

Preclinical

Authors

NLNibedita LenkaNational Centre for Cell Science ABAruna BasuCase Western Reserve University JMJayati MullickUniversity of Pennsylvania

Discussion

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Implication

No immediate clinical implications; leaves open bHLH protein roles in human cardiac differentiation pending further validation.

Structured PICO

Population

C2C12 skeletal myocytes and H9C2 cardiomyocytes

Intervention

Characterization of the distal promoter region of the rat gene for muscle-specific cytochrome oxidase VIII (COX VIII(H)) and coexpression with Id

Outcome

Transcriptional activation and protein complex formation at E1 and E2 boxessurrogate

The study demonstrates that an E box binding basic helix-loop-helix protein is involved in the cardiac muscle-specific regulation of the COX VIII(H) promoter.

Cite This Study

Lenka et al. (1996) studied this question.

synapsesocial.com/papers/6a19674efa25ab5db6d97692 https://doi.org/10.1074/jbc.271.47.30281

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The Role of an E Box Binding Basic Helix Loop Helix Protein in the Cardiac Muscle-specific Expression of the Rat Cytochrome Oxidase Subunit VIII Gene

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Role of an E Box Binding Basic Helix Loop Helix Protein in the Cardiac Muscle-specific Expression of the Rat Cytochrome Oxidase Subunit VIII Gene

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider