Population
Primary cultures of neonatal rat cardiomyocytes, skeletal myogenic C2 cell line, and nonmuscle cardiac cells
Comparison
Transfection with human cardiac alpha-actin… vs Transfection with control vectors or incubation…
Design
Preclinical
Authors
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Findings remain preclinical; extends MyoD analogy to cardiac actin regulation but leaves open human relevance.
Myocardial activation of the human cardiac alpha-actin gene requires a basic helix-loop-helix protein that interacts with the E-box element, functioning analogously to MyoD in skeletal muscle.
Sartorelli et al. (1992) studied this question.
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