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April 1, 1999Molecular and Cellular BiologyOpen Access

Myogenic Basic Helix-Loop-Helix Proteins and Sp1 Interact as Components of a Multiprotein Transcriptional Complex Required for Activity of the Human Cardiac α-Actin Promoter

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Authors

EBElżbieta BiesiadaHouse Clinic YHYasuo HamamoriNiigata University of Pharmacy and Medical and Life Sciences LKLarry KedesUniversity of Southern California

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Implication

Requires further validation before clinical consideration; leaves open the therapeutic relevance of promoter activation mechanisms in heart disease.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Biesiada et al. (1999) studied this question.

synapsesocial.com/papers/6a90f7f855de849fda7a71f3 https://doi.org/10.1128/mcb.19.4.2577

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1In Vivo Footprinting of a Muscle Specific Enhancer by Ligation Mediated PCR1989 · 965 citations
2CArG boxes in the human cardiac alpha-actin gene are core binding sites for positive trans-acting regulatory factors.1987 · 85 citations
3Duplicated CArG Box Domains Have Positive and Mutually Dependent Regulatory Roles in Expression of the Human α-Cardiac Actin Gene1987 · 192 citations
4Regulation of Transcription from the Human Muscle Phosphofructokinase P2 Promoter by the Sp1 Transcription Factor1994 · 13 citations
5Novel clustering of Sp1 transcription factor binding sites at the transcription initiation site of the human muscle phosphofructokinase P1 promoter1994 · 19 citations