May 1, 1996Journal of Biological ChemistryOpen Access

Serum Response Factor Mediates AP-1-dependent Induction of the Skeletal α-Actin Promoter in Ventricular Myocytes

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Population

Ventricular myocytes

Design

Preclinical

Authors

PPPierre ParadisInstitute for Medical Research WMW. Robb MacLellanHeart Failure & Transplant NBNarasimhaswamy S. BelaguliBaylor College of Medicine

Discussion

Member takes

Implication

Requires validation in human models before any clinical consideration; leaves open AP-1/SRF targeting in cardiac hypertrophy.

Structured PICO

Population

Ventricular myocytes

Intervention

Cotransfection with Fos, Jun, or JunB, and skeletal alpha-actin (SkA) reporter genes

Outcome

SkA transcription activation and molecular interactions (binding/synergy)surrogate

AP-1 factors mediate the induction of the hypertrophy-associated skeletal alpha-actin gene in ventricular myocytes via serum response factor (SRF), without direct binding.

Cite This Study

Paradis et al. (1996) studied this question.

synapsesocial.com/papers/6a6f82ace71d69abee08110e https://doi.org/10.1074/jbc.271.18.10827

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Serum Response Factor Mediates AP-1-dependent Induction of the Skeletal α-Actin Promoter in Ventricular Myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Serum Response Factor Mediates AP-1-dependent Induction of the Skeletal α-Actin Promoter in Ventricular Myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider