Population
Muscle cells and fibroblastic cells (in vitro and in vivo models)
Design
Preclinical
Authors
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Requires validation in human models before clinical consideration; extends knowledge of shared transcriptional mechanisms in skeletal and cardiac muscle.
The study identifies a common transcription factor (CBF) binding to CArG boxes that regulates both skeletal and cardiac alpha-actin gene expression in muscle cells.
Muscat et al. (1988) studied this question.
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