Key result
Normal beta actin promoter activity depends on the binding of a ubiquitous factor to the CCAAT-box element, with the sequence GCCAATCAG being sufficient for recognition.
Population
Various cells and tissues, including differentiated muscle and HeLa cells
Design
Preclinical
Authors
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Does not alter clinical practice; extends foundational promoter insights for future cardiovascular gene studies.
The beta actin promoter requires binding of a ubiquitous factor to the CCAAT-box element for normal activity, suggesting a common role in transcriptional activation across eukaryotic promoters.
Quitschke et al. (1989) studied this question. Normal beta actin promoter activity depends on the binding of a ubiquitous factor to the CCAAT-box element, with the sequence GCCAATCAG being sufficient for recognition.
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