Key result
Heterodimers of myogenin or MyoD with E12 bind an E box adjacent to a CArG3 box, which is required but not sufficient alone for muscle-specific induction of the cardiac alpha-actin promoter.
Direct and indirect pathways involving multiple cis-acting elements (E box and CArG3) mediate the induction of the cardiac alpha-actin promoter by myogenin and MyoD.
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Findings remain preclinical; leaves open human cardiac promoter regulation and therapeutic relevance.
French et al. (1991) studied Gene regulation in skeletal muscle development. Myogenin and MyoD heterodimers with E12 was evaluated on Binding and transactivation of the cardiac alpha-actin promoter. Heterodimers of myogenin or MyoD with E12 bind an E box adjacent to a CArG3 box, which is required but not sufficient alone for muscle-specific induction of the cardiac alpha-actin promoter.
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