Why the study?
Are serum angiopoietin-2 (Ang-2) levels elevated and correlated with disease progression in patients with coronary heart disease?
Are serum angiopoietin-2 (Ang-2) levels elevated and correlated with disease progression in patients with coronary heart disease?
Serum Ang-2 levels are elevated in coronary heart disease and correlate with angiographic severity (Gensini scores) and inflammation (hs-CRP), suggesting potential utility as a biomarker for disease progression.
Coronary heart disease (CHD) is characterized by inflammatory process and endothelial dysfunction. To investigate angiopoietin-2 (Ang-2) profiles, we evaluated serum Ang-2 levels in different types of CHD in 166 subjects. Ang-2 was measured by enzyme-linked immunosorbent assay. Serum Ang-2 levels were significantly elevated in patients with CHD and gradually increased with advance of CHD. Ang-2 was positively correlated with Gensini scores and hs-CRP. Ang-2 might have potential implication in detecting and monitoring the progression of CHD.
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Wang et al. (2012) studied this question.
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