Key result
Angiopoietin-2 serum levels progressively increased with heart failure severity and strongly predicted CHF diagnosis (AUC 0.94; 95% CI 0.88-0.99; P<0.001).
Why the study?
Do serum levels of angiogenesis markers correlate with haemodynamic and functional impairment in patients with chronic heart failure?
Population
87 patients with stable chronic heart failure of increasing severity and 14 healthy subjects matched for age…
Comparison
Measurement of serum angiogenesis markers. vs Healthy subjects matched for age and sex.
Design
Cross-sectional
Authors
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Angiopoietin-2 associates with HF severity; hypothesis-generating for biomarker utility, prospective studies needed before clinical adoption.
Observational (n=101)
Do serum levels of angiogenesis markers correlate with haemodynamic and functional impairment in patients with chronic heart failure?
Effect estimate: AUC 0.94 (95% CI 0.88-0.99)
p-value: p=<0.001
Serum levels of angiopoietin-2 and other angiogenesis markers progressively increase with haemodynamic and functional decline in chronic heart failure, suggesting a role in endothelial repair mechanisms.
Eleuteri et al. (2011) conducted an observational in Chronic heart failure (n=101). Angiopoietin-2 serum levels vs. Healthy subjects was evaluated on Chronic heart failure diagnosis (AUC 0.94, 95% CI 0.88-0.99, p=<0.001). Angiopoietin-2 serum levels progressively increased with heart failure severity and strongly predicted CHF diagnosis (AUC 0.94; 95% CI 0.88-0.99; P<0.001).
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