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June 11, 2020Chinese Medical JournalOpen Access

Higher serum angiopoietin 2 levels are independently associated with coronary microvascular dysfunction in patients with angina in the absence of obstructive coronary artery disease

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Why the study?

Circulating Ang-2 levels are elevated in obstructive CAD, but its association with coronary microvascular dysfunction in patients without obstructive CAD was unclear.

Are higher serum Ang-2 levels associated with impaired coronary flow reserve in patients with angina without obstructive CAD?

Population

125 patients with angina in the absence of obstructive CAD

Comparison

Impaired CFR (CFR <2.5) vs preserved CFR (CFR ≥2.5)

Design

Cross-sectional study

Authors

SCShaomin ChenPeking UniversityDLDan LiHebei Medical UniversityXXXing XingHebei General Hospital

Discussion

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Member takes

Overview

Supports Ang-2 as a hypothesis-generating CMD biomarker in nonobstructive angina; should not yet change practice.

Structured PICO

Are higher serum Ang-2 levels associated with impaired coronary flow reserve in patients with angina without obstructive CAD?

P
Population
125 patients with angina in the absence of obstructive coronary artery disease
I
Intervention
Higher serum Angiopoietin-2 (Ang-2) levels
C
Comparator
Lower serum Ang-2 levels
O
Outcome
Impaired coronary flow reserve (CFR < 2.5) measured by trans-thoracic Doppler echocardiographysurrogate

Higher serum Ang-2 levels are independently associated with coronary microvascular dysfunction in patients with angina but no obstructive CAD, suggesting a potential biomarker for this condition.

Cite This Study

Chen et al. (2020) studied this question.

synapsesocial.com/papers/6a82c55dd88fdfcf4fa0cb82https://doi.org/10.1097/cm9.0000000000000812
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Also Consider

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