Key result
Higher serum Ang-2 levels and the Ang-2/Ang-1 ratio were independently associated with the development of heart failure during hospitalization in patients with acute myocardial infarction (Ang-2/Ang-1 OR 4.306).
Why the study?
Are elevated serum Ang-2 levels and Ang-2/Ang-1 ratio associated with the development of heart failure in patients with acute myocardial infarction?
Population
103 consecutive patients with first ST-segment elevation myocardial infarction treated with primary…
Design
Cohort, Assays were performed by an investigator blinded to the sample sources.
Follow-up
during hospitalization
Authors
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May aid in-hospital HF risk stratification in AMI; hypothesis-generating and requires prospective validation before clinical adoption.
Observational (n=103)
No
Are elevated serum Ang-2 levels and Ang-2/Ang-1 ratio associated with the development of heart failure in patients with acute myocardial infarction?
Odds Ratio: 4.306 (95% CI 1.287–14.406)
p-value: p=0.018
Elevated serum Ang-2 levels and Ang-2/Ang-1 ratio at admission are independent predictors of heart failure development during hospitalization in patients with acute myocardial infarction.
Chen et al. (2013) conducted an observational in Acute myocardial infarction (STEMI) (n=103). Serum Angiopoietin-2 to Angiopoietin-1 ratio (Ang-2/Ang-1) vs. Lower Ang-2/Ang-1 ratio was evaluated on Heart failure (Killip Class ≥II) during hospitalization (OR 4.306, 95% CI 1.287-14.406, p=0.018). Higher serum Ang-2 levels and the Ang-2/Ang-1 ratio were independently associated with the development of heart failure during hospitalization in patients with acute myocardial infarction (Ang-2/Ang-1 OR 4.306).
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