Angiopoietins as Predictor Indexes in COVID-19 Patients in Delta and Omicron Waves

Figure 1. Histogram of absolute frequencies for Ang-1 level. Sample size is n = 90.

Figure 2. Box plot of Ang-1 for the three groups of patients: outpatient, non-ICU and ICU. Sample size is n = 30 for each patient group. The “o” represents outliers.

Figure 3. Histogram of absolute frequencies for Ang-2. Sample size is n = 90.

Figure 4. Box plot of Angiopoietin-2 for the three groups of patients: outpatient, non-ICU and ICU (Intensive Care Unit, ICU). Sample size is n = 30 for each patient group. The “o” represents outliers, while “*” represents extreme outliers.

Figure 5. Histogram of absolute frequencies for Ang-2/Ang-1 ratio. Sample size is n = 90.

Figure 6. Box plot of Ang-2/Ang-1 for the three groups of patients: outpatient, non-ICU, and ICU (Intensive Care Unit, ICU). Sample size is n = 30 for each patient group. The “o” represents outliers, while “*” represents extreme outliers.

Figure 7. Receiver Operating Characteristic (ROC) curve for Ang-2/Ang-1 ratio for outpatient and non-ICU patients, area under the ROC curve (AUC) 0.849, 95% Confidence Interval from 0.738 to 0.959, p-value < 0.001. Blue line represents sensitivity vs. 1 − specificity (1 minus specificity), while the red line represents the diagonal, i.e., the line of no discrimination or the reference line. Sample size is n = 30 for each patient group.

Figure 8. Receiver Operating Characteristic (ROC) curve for Ang-2/Ang-1 ratio for non-ICU and ICU patients, area under the ROC curve (AUC) 0.734, 95% Confidence Interval from 0.602 to 0.867, p-value = 0.002. Blue line represents sensitivity vs. 1 − specificity (1 minus specificity), while the red line represents the diagonal, i.e., the line of no discrimination or the reference line. Sample size is n = 30 for each patient group.