Key result
Elevated Ang-2 and Ang-2/Ang-1 ratio around STEMI PCI correlate with higher peak troponin T.
Why the study?
Are dynamic changes in serum Ang-1 and Ang-2 levels associated with myocardial damage in STEMI patients treated with primary PCI?
Observational (n=85)
Are dynamic changes in serum Ang-1 and Ang-2 levels associated with myocardial damage in STEMI patients treated with primary PCI?
Circulating Ang-2 and the Ang-2/Ang-1 ratio may serve as biomarkers for the extent of myocardial damage in STEMI patients undergoing primary PCI.
Answers are grounded in this paper and cite their sources.
May indicate myocardial damage extent in STEMI; hypothesis-generating and requires prospective validation before clinical adoption.
CONTEXT: Angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) play divergent roles in myocardial ischemia and reperfusion injury. OBJECTIVE: To investigate serum Ang-1 and Ang-2 levels in ST-segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PCI). METHODS: Serum Ang-1 and Ang-2 were measured in 85 STEMI patients in the first week after PCI. RESULTS: Ang-1, Ang-2 and Ang-2/Ang-1 ratio (Ang-2/1) were all increased at admission, and had dynamic changes after PCI. Ang-2 and Ang-2/1 at admission and 2 h after PCI were positively correlated with peak cardiac troponin T levels. CONCLUSION: The extent of myocardial damage may be linked to circulating Ang-2 and Ang-2/1.
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Chen et al. (2012) conducted an observational in ST-segment elevation myocardial infarction (STEMI) (n=85). Serum Ang-1 and Ang-2 levels was evaluated on Correlation with peak cardiac troponin T levels. In 85 STEMI patients, circulating Ang-2 and the Ang-2/Ang-1 ratio at admission and 2 hours after primary PCI were positively correlated with peak cardiac troponin T levels.
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