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May 30, 2012Biomarkers

Dynamic changes in serum angiopoietin-1, angiopoietin-2, and angiopoietin-2/angiopoietin-1 ratio in acute myocardial infarction patients treated with primary percutaneous coronary intervention

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Key result

Elevated Ang-2 and Ang-2/Ang-1 ratio around STEMI PCI correlate with higher peak troponin T.

  • n=85

Why the study?

Are dynamic changes in serum Ang-1 and Ang-2 levels associated with myocardial damage in STEMI patients treated with primary PCI?

Population

85 ST-segment elevation myocardial infarction (STEMI) patients

Design

Cohort

Follow-up

first week after PCI

Authors

SCShaomin ChenLGLijun GuoMCMing Cui

Discussion

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Member takes

Overview

May indicate myocardial damage extent in STEMI; hypothesis-generating and requires prospective validation before clinical adoption.

Study Design

Type

Observational (n=85)

Structured PICO

Are dynamic changes in serum Ang-1 and Ang-2 levels associated with myocardial damage in STEMI patients treated with primary PCI?

P
Population
85 STEMI patients treated with primary PCI, with serum angiopoietin levels measured during the first week post-procedure.
E
Exposure
Primary percutaneous coronary intervention (PCI) and measurement of serum Ang-1 and Ang-2
O
Outcome
Serum Ang-1, Ang-2, and Ang-2/Ang-1 ratio levels and their correlation with peak cardiac troponin T levelssurrogate

Circulating Ang-2 and the Ang-2/Ang-1 ratio may serve as biomarkers for the extent of myocardial damage in STEMI patients undergoing primary PCI.

Cite This Study

Chen et al. (2012) conducted an observational in ST-segment elevation myocardial infarction (STEMI) (n=85). Serum Ang-1 and Ang-2 levels was evaluated on Correlation with peak cardiac troponin T levels. In 85 STEMI patients, circulating Ang-2 and the Ang-2/Ang-1 ratio at admission and 2 hours after primary PCI were positively correlated with peak cardiac troponin T levels.

synapsesocial.com/papers/6aa4d6f1814b48fd3caa25c3https://doi.org/10.3109/1354750x.2012.684152
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Percutaneous Coronary Intervention on Serum Angiopoietin-2 in Patients with Coronary Heart Disease2016 · 13 citations
  2. 2Association between serum angiopoietin-2 concentrations and periprocedural myocardial injury in patients undergoing elective percutaneous coronary intervention2020 · 3 citations
  3. 3Plasma Angiopoietin-1, Angiopoietin-2, Angiopoietin Receptor Tie-2, and Vascular Endothelial Growth Factor Levels in Acute Coronary Syndromes2004 · 189 citations
  4. 4Association of serum angiopoietin-1, angiopoietin-2 and angiopoietin-2 to angiopoietin-1 ratio with heart failure in patients with acute myocardial infarction2013 · 31 citations
  5. 5Reciprocal regulation of angiopoietin-1 and angiopoietin-2 following myocardial infarction in the rat*12004 · 60 citations