What does this research mean for the field?

Pre-procedural serum angiopoietin-2 (Ang-2) levels do not predict periprocedural myocardial injury (PMI) after elective percutaneous coronary intervention, but post-procedural changes in Ang-2 levels are closely associated with the occurrence of PMI. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 17, 2020AgingOpen Access

Association between serum angiopoietin-2 concentrations and periprocedural myocardial injury in patients undergoing elective percutaneous coronary intervention

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Why the study?

Do pre-procedural serum Angiopoietin-2 (Ang-2) levels predict periprocedural myocardial injury in patients undergoing elective PCI?

Population

Patients undergoing elective PCI

Comparison

PMI vs non-PMI patients

Follow-up

Postoperative day 3

Authors

WJWen JianBoston University JGJiahui GuanCommunity Care WZWenbo ZhengJilin University

Discussion

Member takes

Implication

Baseline Ang-2 should not inform PMI risk stratification before elective PCI; leaves open NT-proBNP integration and post-procedural dynamics.

Structured PICO

Do pre-procedural serum Angiopoietin-2 (Ang-2) levels predict periprocedural myocardial injury in patients undergoing elective PCI?

Population

145 consecutive patients undergoing elective percutaneous coronary intervention (PCI) with negative high-sensitivity troponin T (hsTnT) at admission. Mean age 61 ± 10 years, 83% male. Single-center (China). Key exclusions: acute myocardial infarction, acute heart failure, elevated hsTnT at admission, tachyarrhythmia, valvular or congenital heart disease, end-stage renal disease.

Intervention

Measurement of serum Angiopoietin-2 (Ang-2) levels at admission, and on postoperative days 1 and 3

Outcome

Periprocedural myocardial injury (PMI), defined as elevation of hsTnT above 5 x 99th percentile upper reference limit occurring within 24 hours after the proceduresurrogate

Pre-procedural Ang-2 levels do not predict periprocedural myocardial injury in elective PCI, but post-procedural Ang-2 dynamics are altered in patients who experience injury, and baseline NT-proBNP is an independent predictor.

Limitations

Single-center observational study with a relatively small sample size
Post-procedural evidence of new myocardial ischemia was not considered (type 4a MI criteria not fully met)
Extraction time of fasting blood samples was not strictly controlled

Cite This Study

Jian et al. (2020) studied this question.

synapsesocial.com/papers/6a19948760e90a7f5fea6be7 https://doi.org/10.18632/aging.102936

Topics

Percutaneous coronary intervention

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Implication

Baseline Ang-2 should not inform PMI risk stratification before elective PCI; leaves open NT-proBNP integration and post-procedural dynamics.

Association between serum angiopoietin-2 concentrations and periprocedural myocardial injury in patients undergoing elective percutaneous coronary intervention

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Association between serum angiopoietin-2 concentrations and periprocedural myocardial injury in patients undergoing elective percutaneous coronary intervention

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider