July 30, 2004Cardiovascular Research

Myocardial ischemia resulted in a sustained increase in Ang-2 expression and a reciprocal decrease in Ang-1 at 24 hours and 1 week, with markedly increased Tie2 phosphorylation at the time of peak Ang-2 elevation.

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Population

Sprague-Dawley rats (model of myocardial infarction)

Comparison

Left coronary artery ligation vs Non-infarcted myocardium

Design

Preclinical

Follow-up

1 week

Authors

RSRobinderpal Sandhu

Discussion

Member takes

Overview

Hypothesis-generating for Ang/Tie2 modulation post-MI; leaves open whether targeting this axis improves outcomes in larger models or humans.

Structured PICO

Population

Sprague-Dawley rats (model of myocardial infarction)

Intervention

Left coronary artery ligation (myocardial ischemia)

Comparator

Non-infarcted myocardium

Outcome

Changes in gene and protein expression of Ang-1, Ang-2, and TIE-2 activitysurrogate

In a rat model of myocardial infarction, reciprocal regulation of Ang-1 and Ang-2 occurs, suggesting Ang-2 plays a predominant role in the post-MI angiogenic response.

Cite This Study

Robinderpal Sandhu (2004) studied this question.

synapsesocial.com/papers/6a71487331a3df8243297e9c https://doi.org/10.1016/j.cardiores.2004.05.013

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July 30, 2004Cardiovascular Research

Myocardial ischemia resulted in a sustained increase in Ang-2 expression and a reciprocal decrease in Ang-1 at 24 hours and 1 week, with markedly increased Tie2 phosphorylation at the time of peak Ang-2 elevation.

View Full Paper

Ask AI

Bookmark

Population

Sprague-Dawley rats (model of myocardial infarction)

Comparison

Left coronary artery ligation vs Non-infarcted myocardium

Design

Preclinical

Follow-up

1 week

Authors

RSRobinderpal Sandhu

Discussion

Member takes

Overview

Hypothesis-generating for Ang/Tie2 modulation post-MI; leaves open whether targeting this axis improves outcomes in larger models or humans.

Structured PICO

Population

Sprague-Dawley rats (model of myocardial infarction)

Intervention

Left coronary artery ligation (myocardial ischemia)

Comparator

Non-infarcted myocardium

Outcome

Changes in gene and protein expression of Ang-1, Ang-2, and TIE-2 activitysurrogate

In a rat model of myocardial infarction, reciprocal regulation of Ang-1 and Ang-2 occurs, suggesting Ang-2 plays a predominant role in the post-MI angiogenic response.

Cite This Study

Robinderpal Sandhu (2004) studied this question.

synapsesocial.com/papers/6a71487331a3df8243297e9c https://doi.org/10.1016/j.cardiores.2004.05.013

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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