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February 1, 2000Journal of Cerebral Blood Flow & MetabolismOpen Access

Induction of Angiopoietin and Tie Receptor mRNA Expression after Cerebral Ischemia–Reperfusion

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Population

Rats in a focal cerebral ischemia model

Comparison

Focal cerebral ischemia-reperfusion vs Sham-operated controls

Design

Preclinical

Follow-up

up to 2 weeks

Authors

TLTeng‐Nan LinCWChien‐Kai WangWCWai-Mui Cheung

Discussion

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Overview

Hypothesis-generating for angiopoietin-Tie involvement in post-ischemic neovascularization; leaves open therapeutic relevance in stroke models.

Structured PICO

P
Population
Rats in a focal cerebral ischemia model
I
Intervention
Focal cerebral ischemia-reperfusion
C
Comparator
Sham-operated controls
O
Outcome
Temporal expression of Angpo-1, Angpo-2, Tie-1, and Tie-2 mRNAsurrogate

Focal cerebral ischemia-reperfusion induces a delayed and prolonged upregulation of angiopoietin and Tie receptor mRNA, suggesting their involvement in post-ischemic neovascularization.

Cite This Study

Lin et al. (2000) studied this question.

synapsesocial.com/papers/6a715040ce524a4339c4e063https://doi.org/10.1097/00004647-200002000-00021
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Increased expression of angiopoietin-2 and Tie2 receptor in a rat model of myocardial ischaemia/reperfusion2003 · 24 citations
  2. 2Reciprocal regulation of angiopoietin-1 and angiopoietin-2 following myocardial infarction in the rat*12004 · 60 citations
  3. 3Differential expression of Tie-2 receptors and angiopoietins in response to in vivo hypoxia in rats2001 · 68 citations
  4. 4Effect of ephrin-B2 on the expressions of angiopoietin-1 and -2 after focal cerebral ischemia/reperfusion2016 · 4 citations
  5. 5Angiopoietin-2 Impairs Revascularization After Limb Ischemia2007 · 112 citations