Key result
In vivo hypoxia exerts inhibitory effects on the angiopoietin-1/Tie-2 receptor pathway through reduction of angiopoietin-1 and upregulation of angiopoietin-2 and -3 in conscious rats.
In vivo hypoxia inhibits the angiopoietin-1/Tie-2 receptor pathway through reduction of angiopoietin-1 and upregulation of angiopoietin-2 and -3 in rats.
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Hypoxia downregulates angiopoietin-1/Tie-2 across rat organs; leaves open HIF-1 mediation in human pulmonary vascular disease.
Abdulmalek et al. (2001) studied Hypoxia. In vivo hypoxia (fraction of inspired oxygen of 9-10%) vs. Normoxia was evaluated on Expression of Tie-2 receptors, angiopoietins, and HIF-1 alpha. In vivo hypoxia exerts inhibitory effects on the angiopoietin-1/Tie-2 receptor pathway through reduction of angiopoietin-1 and upregulation of angiopoietin-2 and -3 in conscious rats.
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