Key result
Prolonged mild hypoxia increased rat cerebral cortex capillary density by 60% at 3 weeks, which progressively decreased to prehypoxic values after 3 weeks of normoxic recovery.
Population
Rat brain model
Comparison
Prolonged mild hypoxia followed by normoxic… vs Prehypoxic baseline/normoxic controls
Design
Preclinical
Follow-up
6 weeks (3 weeks hypoxia, 3 weeks normoxia)
Authors
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Reversible hypoxia-induced cerebral angiogenesis in rats; leaves open translation to human cerebrovascular remodeling or angiopoietin-2 therapies.
Angiopoietin-2 may modulate both hypoxia-induced angiogenesis and subsequent vascular regression via apoptosis in the rat brain.
Pichiule et al. (2002) studied Hypoxia adaptation. Prolonged mild hypoxia vs. Normoxic recovery (deadaptation) / prehypoxic values was evaluated on Capillary density in the rat cerebral cortex. Prolonged mild hypoxia increased rat cerebral cortex capillary density by 60% at 3 weeks, which progressively decreased to prehypoxic values after 3 weeks of normoxic recovery.
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