What is the clinical evidence from this study?

Study design: Other. Population: Hypoxia. Intervention: 10% oxygen (chronic hypoxia). Primary outcome: Angiogenesis.

January 19, 2007Journal of Applied Physiology

Cerebral angiogenic factors, angiogenesis, and physiological response to chronic hypoxia differ among four commonly used mouse strains

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Key result

Exposure to 3 weeks of chronic hypoxia induced significant angiogenesis in CD1 (88%), C57Bl/6 (48%), and 129/Sv (41%) mice, but only 12% in Balb/c mice, highlighting strain-dependent responses.

Population

CD1, 129/Sv, C57Bl/6, and Balb/c mice

Design

Preclinical

Follow-up

up to 3 weeks

Authors

NWNicole L. WardVanderbilt University EMElizabeth MooreUniversity of North Carolina at Chapel Hill KNKristen Noon

Discussion

Member takes

Implication

Extends rodent hypoxia models to multiple mouse strains; hypothesis-generating for human angiogenesis with no direct clinical translation.

Structured PICO

Population

CD1, 129/Sv, C57Bl/6, and Balb/c mice exposed to 10% oxygen for up to 3 weeks to evaluate angiogenesis and physiological responses.

Intervention

Exposure to 10% oxygen for up to 3 weeks

Outcome

Angiogenesis, physiological measures (percentage of packed red blood cells, respiration frequency, minute volume), and protein expression of VEGF, Ang1, Ang2, and Tie2surrogate

Genetic heterogeneity significantly influences hypoxia-induced angiogenesis and the regulation of angiogenic proteins in mice, which must be accounted for when designing and interpreting in vivo models.

Cite This Study

Ward et al. (2007) studied Hypoxia. 10% oxygen (chronic hypoxia) was evaluated on Angiogenesis. Exposure to 3 weeks of chronic hypoxia induced significant angiogenesis in CD1 (88%), C57Bl/6 (48%), and 129/Sv (41%) mice, but only 12% in Balb/c mice, highlighting strain-dependent responses.

synapsesocial.com/papers/6ab7810280df2579b124b8d7 https://doi.org/10.1152/japplphysiol.00909.2006

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January 19, 2007Journal of Applied Physiology

Cerebral angiogenic factors, angiogenesis, and physiological response to chronic hypoxia differ among four commonly used mouse strains

View Full Paper

Ask AI

Bookmark

Key result

Exposure to 3 weeks of chronic hypoxia induced significant angiogenesis in CD1 (88%), C57Bl/6 (48%), and 129/Sv (41%) mice, but only 12% in Balb/c mice, highlighting strain-dependent responses.

Population

CD1, 129/Sv, C57Bl/6, and Balb/c mice

Design

Preclinical

Follow-up

up to 3 weeks

Authors

NWNicole L. WardVanderbilt University EMElizabeth MooreUniversity of North Carolina at Chapel Hill KNKristen Noon

Discussion

Member takes

Implication

Extends rodent hypoxia models to multiple mouse strains; hypothesis-generating for human angiogenesis with no direct clinical translation.

Structured PICO

Population

CD1, 129/Sv, C57Bl/6, and Balb/c mice exposed to 10% oxygen for up to 3 weeks to evaluate angiogenesis and physiological responses.

Intervention

Exposure to 10% oxygen for up to 3 weeks

Outcome

Angiogenesis, physiological measures (percentage of packed red blood cells, respiration frequency, minute volume), and protein expression of VEGF, Ang1, Ang2, and Tie2surrogate

Cite This Study

synapsesocial.com/papers/6ab7810280df2579b124b8d7 https://doi.org/10.1152/japplphysiol.00909.2006

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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