Key result
Exposure of endothelial cells to hypoxia induced Ang2 expression independently of the HIF pathway, likely mediated by COX-2-dependent prostanoids.
Hypoxia-induced Ang2 expression in endothelial cells is mediated by COX-2-dependent prostanoids rather than the classical HIF-1 pathway, providing new insights into angiogenesis regulation.
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Suggests COX-2 as a regulator of endothelial Ang2 in hypoxia; leaves open in vivo and clinical relevance.
Pichiule et al. (2004) studied this question. Hypoxia vs. Normoxia was evaluated on Angiopoietin-2 (Ang2) expression. Exposure of endothelial cells to hypoxia induced Ang2 expression independently of the HIF pathway, likely mediated by COX-2-dependent prostanoids.
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