Key result
PDGF downregulated Ang2 mRNA levels by 75% within 4 hours via rapid mRNA destabilization, whereas IGF-I increased Ang2 expression through transcriptional activation in vascular smooth muscle cells.
Growth factors PDGF and IGF-I differentially regulate Ang2 expression in vascular smooth muscle cells through distinct transcriptional and posttranscriptional mechanisms.
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These VSMC findings are hypothesis-generating; leaves open any in vivo or clinical relevance to vascular remodeling.
Phelps et al. (2005) studied this question. PDGF and IGF-I was evaluated on Ang2 mRNA and protein levels, transcription rates, and mRNA half-life. PDGF downregulated Ang2 mRNA levels by 75% within 4 hours via rapid mRNA destabilization, whereas IGF-I increased Ang2 expression through transcriptional activation in vascular smooth muscle cells.
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