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May 20, 2006AJP Heart and Circulatory Physiology

Signaling and regulation of endothelial cell survival by angiopoietin-2

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Key result

Angiopoietin-2 promoted endothelial cell survival and attenuated apoptosis through ERK1/2 and PI3-kinase pathways, but did not affect cell migration.

Population

Cultured human umbilical vein endothelial cells

Design

Preclinical

Authors

RHRania HarfoucheL-3 Communications (United States)SHSabah N. A. HussainMcGill University Health Centre

Discussion

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Implication

May inform endothelial protection research in vascular models; leaves open differential Ang-2 therapeutic roles versus Ang-1 pending in vivo validation.

Structured PICO

P
Population
Cultured human umbilical vein endothelial cells
I
Intervention
Angiopoietin-2 (Ang-2) at 150 and 300 ng/ml
O
Outcome
Signaling pathways (phosphorylation of Tie-2 receptors, Akt, ERK1/2, p38, and JNK/SAPK) and biological effects (cell migration, in vitro wound healing, and apoptosis/survival)surrogate

Ang-2 promotes endothelial cell survival via ERK1/2 and PI3-kinase pathways but does not strongly promote cell migration, differing from Ang-1 in its interaction with VEGF.

Cite This Study

Harfouche et al. (2006) studied this question. Angiopoietin-2 was evaluated on Cell survival, migration, and signaling pathway phosphorylation. Angiopoietin-2 promoted endothelial cell survival and attenuated apoptosis through ERK1/2 and PI3-kinase pathways, but did not affect cell migration.

synapsesocial.com/papers/6a92fb8934a8596a08575c84https://doi.org/10.1152/ajpheart.01318.2005
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Roles of reactive oxygen species in angiopoietin‐1/tie‐2 receptor signaling2005 · 123 citations
  2. 2Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses2004 · 179 citations
  3. 3Direct Cell Adhesion to the Angiopoietins Mediated by Integrins2001 · 265 citations
  4. 4Angiopoietin-1 and Angiopoietin-2 Share the Same Binding Domains in the Tie-2 Receptor Involving the First Ig-like Loop and the Epidermal Growth Factor-like Repeats2003 · 200 citations
  5. 5Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie22005 · 228 citations