Population
Cultured endothelial cells
Comparison
Angiopoietin 1 (Ang1) vs Angiopoietin 2 (Ang2) or untreated control
Design
Preclinical
Authors
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Ang1 mitogenic effects in endothelial cells are hypothesis-generating for angiogenesis in cancer; human validation required before any therapeutic consideration.
Angiopoietin 1 exerts mitogenic activity on endothelial cells via activation of MAPK and p70 S6K pathways.
Kanda et al. (2005) studied this question.
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