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October 22, 2004BloodOpen Access

Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses

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Population

Endothelial cells and neutrophils (preclinical model)

Design

Preclinical

Authors

CLCaroline LemieuxBoston Children's HospitalRMRicardo MalibaMontreal Heart InstituteJFJudith FavierInserm

Discussion

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Implication

Angiopoietins promote endothelial-neutrophil interactions in animal models; leaves open their role in human vascular inflammation and remodeling.

Structured PICO

P
Population
Endothelial cells and neutrophils (preclinical model)
I
Intervention
Angiopoietin-1 (Ang1) and Angiopoietin-2 (Ang2)
O
Outcome
Proinflammatory activities (P-selectin translocation and neutrophil adhesion onto endothelial cells)surrogate

Angiopoietins 1 and 2 can directly activate neutrophils and endothelial cells to promote proinflammatory responses, potentially facilitating vascular remodeling and angiogenesis.

Cite This Study

Lemieux et al. (2004) studied this question.

synapsesocial.com/papers/6a82c55ed88fdfcf4fa0cb88https://doi.org/10.1182/blood-2004-09-3531
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Also Consider

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  1. 1Leakage-Resistant Blood Vessels in Mice Transgenically Overexpressing Angiopoietin-11999 · 1,368 citations
  2. 2Inhibition of leukocyte adherence by anti-CD18 monoclonal antibody attenuates reperfusion injury in the rabbit ear.1990 · 203 citations
  3. 3Cytokine production of neutrophils is limited to interleukin‐81996 · 111 citations
  4. 4Platelet-Activating Factor-Induced Endothelial Cell Expression of Adhesion Molecules and Modulation of Surface Glycocalyx, Evaluated by Electron Spectroscopy for Chemical Analysis1994 · 38 citations
  5. 5Distinct platelet-activating factor binding sites in synaptic endings and in intracellular membranes of rat cerebral cortex.1990 · 211 citations