February 12, 2014PLoS ONEOpen Access

Angiopoietin-1 Upregulates De Novo Expression of Il-1β and Il1-Ra, and the Exclusive Release of Il1-Ra from Human Neutrophils

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Why the study?

Does Angiopoietin-1 or Angiopoietin-2 modulate inflammatory signals (IL-1β and IL-1RA) in human neutrophils?

Structured PICO

Does Angiopoietin-1 or Angiopoietin-2 modulate inflammatory signals (IL-1β and IL-1RA) in human neutrophils?

Population

Human neutrophils (in vitro model)

Intervention

Angiopoietin-1 (Ang1) (10(-8) M) and Angiopoietin-2 (Ang2)

Comparator

PBS-control

Outcome

mRNA expression of 84 inflammatory cytokines and their receptors, specifically IL-1β and IL-1RA, and intracellular/extracellular protein levelssurrogate

Angiopoietin-1 selectively alters the balance of neutrophil-derived inflammatory cytokines by upregulating IL-1β and IL-1RA, favoring the blockade of IL-1 activity.

Discussion

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Implication

Ang1 may alter neutrophil IL-1 balance in inflammation; leaves open translation to human cardiovascular disease or therapy.

Cite This Study

Haddad et al. (2014) studied this question.

synapsesocial.com/papers/6a8567ecafd961f1253da2e1 https://doi.org/10.1371/journal.pone.0088980

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Angiopoietin-1 Upregulates De Novo Expression of Il-1β and Il1-Ra, and the Exclusive Release of Il1-Ra from Human Neutrophils

Structured PICO

Discussion

Implication

Cite This Study

Angiopoietin-1 Upregulates De Novo Expression of Il-1β and Il1-Ra, and the Exclusive Release of Il1-Ra from Human Neutrophils

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider