Key result
Angiopoietin-1 and angiopoietin-2 drive Tie-2 dependent neutrophil chemotaxis and inhibit VEGF-directed migration.
Angiopoietin-1 and -2 modulate neutrophilic inflammation by exerting migratory effects and arresting VEGF-mediated chemotaxis via the Tie-2 receptor.
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May modulate neutrophil recruitment in microcirculation; leaves open Tie-2 as a therapeutic target in human inflammatory disease.
Sturn et al. (2005) studied Healthy. Angiopoietin-1 and angiopoietin-2 was evaluated on Neutrophil migration. Angiopoietin-1 and angiopoietin-2 exerted Tie-2 dependent chemotactic effects on human neutrophils and inhibited VEGF-directed migration.
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