Angiopoietin-1 and -2 induce rapid, calcium-dependent P-selectin translocation in endothelial cells via phospholipase C-gamma activation, highlighting a mechanistic link between angiogenesis and inflammation.
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Suggests angiopoietin-Tie2 signaling rapidly couples angiogenesis to endothelial inflammation; leaves open relevance to human vascular disease.
Maliba et al. (2007) studied this question.
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