May 3, 2016Animal Cells and SystemsOpen Access

Angiogenic activity of endothelial progenitor cells through angiopoietin-1 and angiopoietin-2

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Population

Isolated endothelial progenitor cells (EPCs)

Comparison

Exposure to Angiopoietin-1 and Angiopoietin-2 at… vs Comparison between Ang-1 and Ang-2 effects

Design

Preclinical

Follow-up

14 days

Authors

VSVahid SiavashiAmirkabir University of Technology RSReyhaneh SaririUniversity of Guilan SNSeyed Mahdi NassiriUniversity of Tehran

Discussion

Member takes

Implication

Ang-1 promotes superior EPC maturation and function versus Ang-2 in vitro; leaves open therapeutic translation to in vivo angiogenesis.

Structured PICO

Population

Isolated endothelial progenitor cells (EPCs)

Intervention

Exposure to Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) at concentrations of 25 and 50 ng/ml over a course of 7 and 14 days

Comparator

Comparison between Ang-1 and Ang-2 effects

Outcome

Angiogenic properties including vascular endothelial growth factor (VEGF) concentration, in vitro tubulogenesis, EPC migratory capacity, Tie-2 expression, clonogenicity, and mature endothelium markerssurrogate

Ang-1 is more potent than Ang-2 in inducing functional and mature vascular-like behavior in endothelial progenitor cells in vitro.

Cite This Study

Siavashi et al. (2016) studied this question.

synapsesocial.com/papers/6a721717e5469ee92be24342 https://doi.org/10.1080/19768354.2016.1189961

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Angiogenic activity of endothelial progenitor cells through angiopoietin-1 and angiopoietin-2

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiogenic activity of endothelial progenitor cells through angiopoietin-1 and angiopoietin-2

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider