Key result
Angiopoietin-1-Tie2 signaling regulates both vascular maintenance and angiogenesis through distinct mechanisms depending on the presence or absence of endothelial cell-cell contacts.
Answers are grounded in this paper and cite their sources.
This review elucidates how Ang1-Tie2 signaling mediates both vascular stabilization and angiogenesis depending on the presence or absence of cell-cell contacts.
Angiopoietin-1 (Ang1) binds to and activates Tie2 receptor tyrosine kinase. Ang1-Tie2 signal has been proposed to exhibit two opposite roles in the controlling blood vessels. One is vascular stabilization and the other is vascular angiogenesis. There has been no answer to the question as to how Tie2 induces two opposite responses to the same ligand. Our group and Dr. Alitalos group have demonstrated that trans-associated Tie2 at cell-cell contacts and extracellular matrix (ECM)-anchored Tie2 play distinct roles in the endothelial cells. The complex formation depends on the presence or absence of cell-cell adhesion. Here, we review how Ang1-Tie2 signal regulates vascular maintenance and angiogenesis. We further point to the unanswered questions that must be clarified to extend our knowledge of vascular biology and to progress basic knowledge to the treatment of the diseases in which Ang1-Tie2-mediated signal is central.
No takes yet. Share an insight, caveat, or question.
Fukuhara et al. (2009) conducted a review in Vascular biology and angiogenesis. Angiopoietin-1 (Ang1) and Tie2 signaling was evaluated. Angiopoietin-1-Tie2 signaling regulates both vascular maintenance and angiogenesis through distinct mechanisms depending on the presence or absence of endothelial cell-cell contacts.
Synapse has enriched 10 related papers. Consider them for comparative context: