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October 9, 2006Proceedings of the National Academy of SciencesOpen Access

Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells

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Population

Stressed endothelial cells (in vitro) and in vivo models

Design

Preclinical

Authors

CDChristopher DalyThe University of SydneyEPElizabeth PasnikowskiMount Sinai HospitalEBElena BurovaRegeneron (United States)

Discussion

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Implication

Challenges Ang-2 as sole Tie2 antagonist in stressed endothelium; hypothesis-generating in animals, human validation required.

Structured PICO

P
Population
Stressed endothelial cells (in vitro) and in vivo models
I
Intervention
Angiopoietin-2 (Ang-2) expression induced by FOXO1; RNAi and blocking antibodies
O
Outcome
Tie2/Akt signaling activity, FOXO1-regulated transcription, apoptosis, and vascular leaksurrogate

Angiopoietin-2 acts as an autocrine Tie2 agonist and protective factor in stressed endothelial cells, challenging the prevailing model of it being solely a Tie2 blocker.

Cite This Study

Daly et al. (2006) studied this question.

synapsesocial.com/papers/6a7d3196ab1caed3bf7496afhttps://doi.org/10.1073/pnas.0607538103
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Also Consider

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