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June 24, 2013PLoS ONEOpen Access

Angiopoietin-2 in Adults with Congenital Heart Disease and Heart Failure

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Key result

Circulating Angiopoietin-2 levels were significantly elevated in adults with congenital heart disease and heart failure, correlating with NYHA class and ventricular dysfunction comparably to NT-proBNP.

Why the study?

Does Angiopoietin-2 correlate with heart failure severity and exercise capacity in adults with congenital heart disease?

Population

91 adults with congenital heart disease, mean age 30.4 years, 59.3% male, recruited at a single center in…

Design

Cross-sectional

Authors

ALAlexander LukaszGBGernot BeutelPKPhilipp Kümpers

Discussion

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Member takes

Overview

Supports Ang-2 as candidate biomarker in ACHD-HF; hypothesis-generating and should not yet change practice.

Study Design

Type

Cross-Sectional (n=91)

Multicenter

No

Structured PICO

Does Angiopoietin-2 correlate with heart failure severity and exercise capacity in adults with congenital heart disease?

P
Population
91 adults with congenital heart disease (mean age 30.4 years, 40.7% female) evaluated in a cross-sectional study to assess the diagnostic value of circulating endothelial factors for heart failure.
E
Exposure
Measurement of circulating angiogenic factors including Angiopoietin-2 (Ang-2), Angiopoietin-1 (Ang-1), VEGF, and sTie2, alongside NT-proBNP.
O
Outcome
Correlation of Ang-2 and NT-proBNP with New York Heart Association (NYHA) class, systemic ventricular function, and parameters of cardiopulmonary exercise testing.surrogate

Main Result

Absolute Event Rate: 8.23% vs 2.52%

p-value: p=<0.0001

Angiopoietin-2 correlates with heart failure severity in adults with congenital heart disease and is significantly elevated in patients with single ventricle physiology, suggesting its potential as a biomarker in this population.

Limitations

  • Cross-sectional design limits the ability to determine the predictive value of the biomarkers.
  • Small number of patients enrolled, especially those with a single ventricle physiology.
  • Results are hypothesis-generating and require validation in a prospective study with a larger patient size.
  • Cross-sectional design
  • Small number of patients enrolled, especially those with a single ventricle
  • Hypothesis-generating character

Cite This Study

Lukasz et al. (2013) conducted a cross-sectional in Congenital Heart Disease and Heart Failure (n=91). Angiopoietin-2 vs. NYHA class I was evaluated on Angiopoietin-2 concentration (ng/ml) in NYHA class III compared to NYHA class I (p=<0.0001). Circulating Angiopoietin-2 levels were significantly elevated in adults with congenital heart disease and heart failure, correlating with NYHA class and ventricular dysfunction comparably to NT-proBNP.

synapsesocial.com/papers/6a85bfb9b451cea71dae79a5https://doi.org/10.1371/journal.pone.0066861
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Asymmetrical Dimethylarginine - More Sensitive than NT-proBNP to Diagnose Heart Failure in Adults with Congenital Heart Disease2012 · 31 citations
  2. 2The usefulness of brain natriuretic peptide in simple congenital heart disease – a systematic review2012 · 28 citations
  3. 3Angiopoietin-1 Regulates Endothelial Cell Survival Through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway2000 · 653 citations
  4. 4Angiopoietin-1 Inhibits Endothelial Cell Apoptosis via the Akt/Survivin Pathway2000 · 639 citations
  5. 5ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM)2008 · 2,708 citations