Why the study?
Does co-administration of losartan or tempol prevent cardiovascular and renal damage induced by chronic aldosterone infusion in Sprague-Dawley rats?
Does co-administration of losartan or tempol prevent cardiovascular and renal damage induced by chronic aldosterone infusion in Sprague-Dawley rats?
In a rat model, the profibrotic, but not hypertrophic, actions of aldosterone are mediated at least in part by reactive oxygen species generation and involve an interaction with the renin-angiotensin system.
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Distinguishes profibrotic from hypertrophic aldosterone effects in rats; extends mechanistic insights but leaves open human relevance.
Iglarz et al. (2004) studied this question.
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