Key result
AT1 and MR blockade normalized protein oxidation in Ang II-infused rats, while eplerenone alone exacerbated plasma and heart aldosterone increases by 2.3- and 1.8-fold, respectively.
Why the study?
Does losartan and/or eplerenone reduce hypertension and oxidative stress in Angiotensin II-infused Sprague-Dawley rats?
Does losartan and/or eplerenone reduce hypertension and oxidative stress in Angiotensin II-infused Sprague-Dawley rats?
In an Angiotensin II-dependent hypertension rat model, receptor signaling rather than elevated blood pressure primarily drives oxidative stress-associated cardiovascular damage.
No takes yet. Share an insight, caveat, or question.
Supports receptor over pressure effects on oxidative stress in Ang II models; leaves open translation and aldosterone effects of MR blockade to humans.
Minas et al. (2015) studied Angiotensin II-dependent hypertension. Losartan and/or eplerenone vs. Control and Ang II infusion alone was evaluated on Oxidative and nitrosative damage. AT1 and MR blockade normalized protein oxidation in Ang II-infused rats, while eplerenone alone exacerbated plasma and heart aldosterone increases by 2.3- and 1.8-fold, respectively.
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