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November 27, 2010AJP Heart and Circulatory PhysiologyOpen Access

Central interactions of aldosterone and angiotensin II in aldosterone- and angiotensin II-induced hypertension

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Why the study?

Does central blockade of MR or AT1R reduce blood pressure in male rats with aldosterone- or angiotensin II-induced hypertension?

Population

Male rats with aldosterone- and angiotensin II-induced hypertension

Comparison

Intracerebroventricular infusions of… vs Scrambled siRNA or control conditions

Design

Preclinical

Authors

BXBaojian XueTBTerry G. BeltzYYYang Yu

Discussion

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Overview

Central MR/AT1R blockade attenuates experimental hypertension in rats; leaves open relevance to human hypertension.

Structured PICO

Does central blockade of MR or AT1R reduce blood pressure in male rats with aldosterone- or angiotensin II-induced hypertension?

P
Population
Male rats with aldosterone- and angiotensin II-induced hypertension
I
Intervention
Intracerebroventricular (icv) infusions of mineralocorticoid receptor (MR) antagonists (spironolactone, RU28318), AT1R antagonist (irbesartan), ROS scavenger (tempol), NADPH oxidase inhibitor (apocynin), or icv injections of recombinant adeno-associated virus carrying siRNA silencers of AT1aR or MR
C
Comparator
Scrambled siRNA or control conditions
O
Outcome
Blood pressure (BP) and heart rate (HR) measured by DSI telemetrysurrogate

Angiotensin II and aldosterone interact centrally in a mutually cooperative manner to induce hypertension, a process involving increased central reactive oxygen species and sympathetic outflow.

Cite This Study

Xue et al. (2010) studied this question.

synapsesocial.com/papers/6a217444582b7ad9ebabb519https://doi.org/10.1152/ajpheart.00847.2010
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