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April 1, 1994British Journal of PharmacologyOpen Access

Augmentation by intracellular ATP of the delayed rectifier current independently of the glibenclamide‐sensitive K‐current in rabbit arterial myocytes

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Population

Rabbit pulmonary artery myocytes

Design

Preclinical

Authors

AEAllan M. EvansUniversity of South AustraliaLCLucie H. ClappThe London CollegeAGAlison M. GurneyManchester Academic Health Science Centre

Discussion

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Implication

Does not support clinical translation; leaves open ATP-independent IKDR modulation in human pulmonary vasculature.

Structured PICO

P
Population
Rabbit pulmonary artery myocytes
I
Intervention
Elevation of intracellular ATP levels by flash photolysis of caged ATP
O
Outcome
Augmentation of the delayed rectifier K-current (IKDR)surrogate

Intracellular ATP augments the delayed rectifier K-current in rabbit pulmonary artery myocytes independently of the glibenclamide-sensitive K-current.

Cite This Study

Evans et al. (1994) studied this question.

synapsesocial.com/papers/6a197ee6c05413006f586b3fhttps://doi.org/10.1111/j.1476-5381.1994.tb14836.x
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