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May 1, 1986British Journal of PharmacologyOpen Access

Comparison of the effects of BRL 34915 and verapamil on electrical and mechanical activity in rat portal vein

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Authors

THThomas C. HamiltonFox Chase Cancer Center SWSheila W. WeirParkside Hospital AWA.H. WestonGoethe University Frankfurt

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Implication

Suggests distinct vasorelaxant mechanism for BRL 34915; leaves open translation to clinical antihypertensive efficacy.

Key Points

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Cite This Study

Hamilton et al. (1986) studied this question.

synapsesocial.com/papers/6a82c603236bcdbab08d5950 https://doi.org/10.1111/j.1476-5381.1986.tb09476.x

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1BRL 34915, A Novel Antihypertensive Agent: Comparison of Effects on Blood Pressure and Other Haemodynamic Parameters with Those of Nifedipine in Animal Models1987 · 90 citations
2SOME EFFECTS OF SODIUM NITROPRUSSIDE, METHOXYVERAPAMIL (D600) AND NIFEDIPINE ON RAT PORTAL VEIN1980 · 58 citations
3The effect of tetraethylammonium chloride on potassium permeability in the smooth muscle cell membrane of canine trachea.1981 · 59 citations
4Ionic Fluxes in the Rat Portal Vein and the Applicability of the Goldman Equation in Predicting the Membrane Potential from Flux Data1973 · 39 citations
5Pharmacokinetic and pharmacodynamic studies with two α‐adrenoceptor antagonists, doxazosin and prazosin in the rabbit1985 · 27 citations