April 1, 1988Circulation Research

Mechanism of action and systemic and regional hemodynamics of the potassium channel activator BRL34915 and its enantiomers.

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Population

Rat portal vein, rabbit aorta, and anesthetized rabbits

Design

Preclinical

Authors

RHRobert P. HofNovartis (Switzerland)UQUlrich QuastUniversity of Tübingen NCNigel S. CookNovartis (Switzerland)

Discussion

Member takes

Implication

Animal data on stereoselective K+ channel activation with regional selectivity should not guide therapy; leaves open human translation and clinical utility.

Structured PICO

Population

Rat portal vein, rabbit aorta, and anesthetized rabbits

Intervention

BRL34915 (BRL) and its enantiomers ((-)-BRL and (+)-BRL)

Outcome

Inhibition of spontaneous mechanical activity, 86Rb+ efflux, inhibition of KCl and angiotensin II responses, and systemic/regional hemodynamic effectssurrogate

BRL34915 is a stereoselective potassium channel activator that produces peripheral vasodilation with regional selectivity for coronary, gastrointestinal, and cerebral vessels.

Cite This Study

Hof et al. (1988) studied this question.

synapsesocial.com/papers/6a8289705bcab2ccdb8d5a6a https://doi.org/10.1161/01.res.62.4.679

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Implication

Animal data on stereoselective K+ channel activation with regional selectivity should not guide therapy; leaves open human translation and clinical utility.

Mechanism of action and systemic and regional hemodynamics of the potassium channel activator BRL34915 and its enantiomers.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanism of action and systemic and regional hemodynamics of the potassium channel activator BRL34915 and its enantiomers.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider