Key result
Intraarterial BRL 34915 increases coronary flow and reduces inotropy and chronotropy in isolated dog hearts.
Population
Isolated, blood-perfused papillary muscle, sinoatrial node, and atrioventricular node preparations of dogs
Design
Preclinical
Authors
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Supports BRL 34915 profiling in canine models; leaves open translation to human therapy.
BRL 34915 exhibits a cardiovascular profile characteristic of potassium channel activators, demonstrating vasoselectivity alongside specific electrophysiological and inotropic effects in canine cardiac models.
Gotanda et al. (1988) studied this question. BRL 34915 was evaluated on Cardiac effects (coronary blood flow, force of contraction, repolarization, ventricular automaticity, sinus rate, AV conduction). Intraarterial injection of BRL 34915 in isolated dog heart preparations increased coronary blood flow and produced negative inotropic and chronotropic effects similar to potassium channel activators.
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