Why the study?
Does BRL 38227 alter electrophysiologic and hemodynamic parameters in anesthetized dogs?
Does BRL 38227 alter electrophysiologic and hemodynamic parameters in anesthetized dogs?
BRL 38227 shortens ventricular conduction and repolarization parameters and decreases blood pressure in a dose-dependent manner, but is highly arrhythmogenic with a low safety margin.
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May signal proarrhythmic risk in development; leaves open human translation and safety margin.
Coussaye et al. (1993) studied this question.
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