Key result
A low dose of levcromakalim (0.01 mg/kg) abolished d-sotalol induced torsades de pointes and normalized QT(U) duration from 550 +/- 40 to 405 +/- 70 msec (P<0.05) in dogs.
Why the study?
Does levcromakalim prevent repolarization-dependent ventricular tachycardias in dogs with chronic AV block?
Does levcromakalim prevent repolarization-dependent ventricular tachycardias in dogs with chronic AV block?
A low dose of levcromakalim specifically prevents repolarization-dependent arrhythmias (torsades de pointes) but not arrhythmias based on other mechanisms in a canine model.
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Experimental support for IK-ATP activation against repolarization-dependent VTs; leaves open clinical translation and safety.
Vos et al. (1994) studied Repolarization-dependent ventricular tachycardias. Levcromakalim was evaluated on Antiarrhythmic action against repolarization-dependent ventricular tachycardias. A low dose of levcromakalim (0.01 mg/kg) abolished d-sotalol induced torsades de pointes and normalized QT(U) duration from 550 +/- 40 to 405 +/- 70 msec (P<0.05) in dogs.
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