Population
Mesenteric artery cells from adult Wistar Kyoto rats and age-matched spontaneously hypertensive rats treated…
Comparison
Levcromakalim (K+ channel opener) vs Cells from normotensive WKY rats and…
Design
Preclinical
Authors
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Reversible KATP impairment in hypertensive rat arteries; hypothesis-generating for human vascular channel dysfunction pending clinical studies.
The action of levcromakalim on ATP-sensitive K+ channels is impaired in mesenteric artery cells of spontaneously hypertensive rats, but this can be corrected by long-term antihypertensive treatment.
Ohya et al. (1996) studied this question.
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