Population
Rabbit pulmonary artery (muscle strips and single cells)
Comparison
Lemakalim (10 microM) vs Glibenclamide, tetrapentylammonium ions…
Design
Preclinical
Authors
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No immediate clinical guidance; leaves open whether KATP activation by lemakalim translates to human pulmonary vasodilation.
Lemakalim induces vasodilation in rabbit pulmonary arteries via the activation of ATP-sensitive K+ channels.
Clapp et al. (1993) studied this question.
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