Population
Single ventricular myocytes enzymatically dissociated from adult male guinea pigs and human ventricular…
Comparison
Lemakalim (3, 10, 30 microM) vs Absence of lemakalim; glibenclamide (1 microM)
Design
Preclinical
Authors
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No immediate clinical translation; leaves open KATP modulation effects in intact hearts or disease models.
Lemakalim exerts a negative inotropic effect and reduces action potential duration in ventricular myocytes by activating ATP-sensitive potassium channels and reducing systolic intracellular calcium.
Jiang et al. (1994) studied this question.
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