Population
Isolated retrogradely perfused and spontaneously beating guinea-pig heart
Design
Preclinical
Authors
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Warrants caution on myocardial efficiency for any development; leaves open translation of coronary effects to clinical models.
In isolated guinea-pig hearts, lemakalim rapidly accumulates, markedly increases coronary flow, and exerts a progressive negative inotropic effect leading to reduced myocardial efficiency.
Mellemkjser et al. (1993) studied this question.
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