Population
Low-frequency-stimulated fast-twitch muscle
Comparison
4-day low-frequency stimulation vs Contralateral muscles
Design
Preclinical
Follow-up
4 days
Authors
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Indicates active-site alterations underlie Ca2+-ATPase inactivation in stimulated muscle; leaves open relevance to human cardiac or skeletal disorders.
Inactivation of SR Ca2+-ATPase in low-frequency-stimulated muscle is likely due to structural alterations in the nucleotide-binding and phosphorylation domains of the active site.
Matsushita et al. (1992) studied this question.
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