Key result
Chronic low-frequency stimulation in rabbit fast-twitch muscle induces partial inactivation of the SR Ca(2+)-ATPase, which is confined to a specific SR vesicle population.
Chronic low-frequency stimulation induces inactivation of Ca2+-ATPase confined to a specific sarcoplasmic reticulum vesicle population in rabbit fast-twitch muscle.
No clinical implications from rabbit data; leaves open vesicle-specific SR Ca2+-ATPase inactivation in human muscle.
Chronic low-frequency stimulation elicits in rabbit fast-twitch muscle a partial inactivation of the sarcoplasmic reticulum (SR) Ca(2+)-ATPase and Ca(2+)-uptake activities. Inactive Ca(2+)-ATPase was enriched in a light microsomal fraction by sucrose density gradient centrifugation after calcium oxalate loading in the presence of ATP. This fraction showed a reduced specific activity and phosphoprotein formation of the Ca(2+)-transport ATPase. These results suggest that the inactivation of the Ca(2+)-ATPase as induced by increased contractile activity, is confined to a specific SR vesicle population.
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Matsushita et al. (1991) studied this question. Chronic low-frequency stimulation was evaluated on Ca(2+)-ATPase and Ca(2+)-uptake activities. Chronic low-frequency stimulation in rabbit fast-twitch muscle induces partial inactivation of the SR Ca(2+)-ATPase, which is confined to a specific SR vesicle population.
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