What question did this study set out to answer?

To evaluate whether antihypertensive drug therapy reduces the rate of stroke recurrence and cardiovascular endpoints in hypertensive stroke survivors.

July 22, 1974JAMA

Effect of Antihypertensive Treatment on Stroke Recurrence

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Implication

Placebo-controlled trial demonstrates no significant reduction in stroke recurrence with antihypertensive therapy, suggesting limited secondary stroke prevention.

Key Points

To evaluate whether antihypertensive drug therapy reduces the rate of stroke recurrence and cardiovascular endpoints in hypertensive stroke survivors.
Placebo-controlled trial evaluating N=452 stroke survivors with baseline recumbent blood pressures of 140–220 mm Hg systolic and 90–115 mm Hg diastolic (mean 167/100 mm Hg).
Participants were assigned to receive either an antihypertensive drug or placebo and followed for a mean period of 3 years.
Antihypertensive therapy did not produce a statistically significant reduction in stroke recurrence compared to placebo.
Cardiovascular disease endpoints overall showed no statistically significant reduction, with the exception of congestive heart failure, which was significantly reduced in the drug-treated group.

Cite This Study

A 1974 study studied this question.

synapsesocial.com/papers/6a198b16196cd56b09ea5ffa https://doi.org/10.1001/jama.1974.03230420021019

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July 22, 1974JAMA

Effect of Antihypertensive Treatment on Stroke Recurrence

View Full Paper

Ask AI

Bookmark

Discussion

Member takes

Implication

Placebo-controlled trial demonstrates no significant reduction in stroke recurrence with antihypertensive therapy, suggesting limited secondary stroke prevention.

Key Points

To evaluate whether antihypertensive drug therapy reduces the rate of stroke recurrence and cardiovascular endpoints in hypertensive stroke survivors.
Placebo-controlled trial evaluating N=452 stroke survivors with baseline recumbent blood pressures of 140–220 mm Hg systolic and 90–115 mm Hg diastolic (mean 167/100 mm Hg).
Participants were assigned to receive either an antihypertensive drug or placebo and followed for a mean period of 3 years.
Antihypertensive therapy did not produce a statistically significant reduction in stroke recurrence compared to placebo.
Cardiovascular disease endpoints overall showed no statistically significant reduction, with the exception of congestive heart failure, which was significantly reduced in the drug-treated group.

Cite This Study

A 1974 study studied this question.

synapsesocial.com/papers/6a198b16196cd56b09ea5ffa https://doi.org/10.1001/jama.1974.03230420021019

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