January 1, 2009Cerebrovascular Diseases
Antihypertensive Treatment after Stroke and All-Cause Mortality – An Analysis of the General Practitioner Research Database (GPRD)
Key result
Antihypertensive treatment after first-ever stroke was associated with higher 5-year survival (68% vs 59%) and a lower risk of premature death (RR 0.62; 95% CI 0.58-0.66; P<0.001).
Why the study?
Does antihypertensive treatment improve survival and reduce stroke recurrence in patients with first-ever stroke?
Population
44,244 patients with first-ever stroke in the UK from 1997 to 2006, of whom 20,147 were diagnosed with…
Comparison
Antihypertensive treatment vs No antihypertensive treatment
Design
Cohort
Follow-up
5 years
Authors
Discussion
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Member takes
Implication
Antihypertensive treatment may improve post-stroke survival; extends observational data but leaves recurrence effect inconclusive.
Study Design
Type
Cohort (n=44,244)
Multicenter
Yes
Structured PICO
Does antihypertensive treatment improve survival and reduce stroke recurrence in patients with first-ever stroke?
P
Population
44,244 patients with first-ever strokes in the UK from 1997 to 2006, followed for up to 5 years.
E
Exposure
Antihypertensive treatment
C
Comparator
No antihypertensive treatment
O
Outcome
Survival (all-cause mortality) and stroke recurrence >1 yearhard clinical
Main Result
Relative Risk: 0.62 (95% CI 0.58–0.66)
p-value: p=< 0.001
In a large real-world cohort, antihypertensive treatment after first-ever stroke was associated with significantly improved survival, though the reduction in late stroke recurrence was not statistically significant.
Cite This Study
Toschke et al. (2009) conducted a cohort in first-ever stroke (n=44,244). Antihypertensive treatment vs. No antihypertensive treatment was evaluated on premature death (RR 0.62, 95% CI 0.58-0.66, p=< 0.001). Antihypertensive treatment after first-ever stroke was associated with higher 5-year survival (68% vs 59%) and a lower risk of premature death (RR 0.62; 95% CI 0.58-0.66; P<0.001).